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Spletter Lab Webpage

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Alternative splicing and RNA regulation in muscle development

Alternative splicing and RNA regulation in muscle developmentAlternative splicing and RNA regulation in muscle development

Publications (Preprints, under review/revision)

2023

Nikonova E., Canela Grimau M., Barz C., Esser A., Bouterwek J., Roy A., Gensler H., Hess M., Straub T., Forne I., Spletter M.L.. 2023 [preprint]. Bruno 1 regulates cytoskeleton dynamics and a temporal splicing transition to promote myofibril assembly, growth and maturation in Drosophila flight muscle. bioRxiv. https://www.biorxiv.org/content/10.1101/2023.06.24.546382v1


Zhang X., Avellaneda J., Spletter M.L., Lemke S., Mangeol P., Habermann B.H., Schnorrer F. 2023 [preprint]. A mechanically regulated liquid-liquid phase separation of the transcriptional regulator Tono instructs muscle development. bioRxiv.

https://www.biorxiv.org/content/10.1101/2023.08.27.555003v1

Publications (peer-reviewed)

2023

Borozan L., Royas Ringeling F., Kao S.-Y., Nikonova E., Monteagudo-Mesas P., Matijevic D., Spletter M.L.*, Canzar S.*. 2023. Counting pseudoalignments to novel splicing events. Bioinformatics: 39(7). btad419. https://doi.org/10.1093/bioinformatics/btad419


2022
Ringeling F.R., Chakraborty S., Vissers C., Reiman D., Patel A.M., Lee K.H., Hong A., Park C.W., Reska T., Gagneur J., Chang H., Spletter M., Yoon K.J., Ming G.L., Song H., Canzar S. 2022. Partitioning RNAs by length improves transcriptome reconstruction from short-read RNA-seq data. Nat Biotechnol. https://doi.org/10.1038/s41587-021-01136-7


Nikonova E.*, Mukherjee A.*, Kamble K.*, Barz C., Nongthomba U., Spletter M.L. 2022. Rbfox1 is required for myofibril development and maintaining fiber-type specific isoform expression in Drosophila muscles. Life Sci Alliance: (5)4: e202101342. https://doi.org/10.26508/lsa.202101342


2021

Kao S.Y.*, Nikonova E.*, Chaabane S., Sabani A., Martitz A., Wittner A., Heemken J., Straub T., Spletter M.L. 2021. A candidate RNAi screen reveals diverse RNA-binding protein phenotypes in Drosophila flight muscle. Cells. 10: 2505.

https://doi.org/10.3390/cells10102505


2020

Nikonova E.*, Kao S.-Y.*, Spletter M.L. 2020. Contributions of alternative splicing to muscle type development and function. Semin Cell Dev Biol. Feb 15. pii: S1084-9521(19)30126-0.  https://doi.org/10.1016/j.semcdb.2020.02.003


2019

Kao, S. Y.*, Nikonova, E.*, Ravichandran, K.*, Spletter, M. L. Dissection of Drosophila melanogaster Flight Muscles for Omics Approaches. J. Vis. Exp. (152), e60309, doi:10.3791/60309 (2019). 

doi: 10.3791/60309


Nikonova E.*, Kao S.-Y.*, Ravichandran K., Wittner A., Spletter M.L. 2019. Conserved functions of RNA-binding proteins in muscle. Int J Biochem Cell Biol. 110: 29-49.

DOI: 10.1016/j.biocel.2019.02.008


2018

Spletter M.L., Barz C., Yeroslaviz A., Zhang X., Lemke B., Bonnard A., Brunner E., Cardone G., Basler K., Habermann B.H., Schnorrer F. 2018. A transcriptomics resource reveals a transcriptional transition during ordered sarcomere morphogenesis in flight muscle. Elife. 7:e34058.

DOI: 10.7554/eLife.34058


Loison O.*, Weitkunat M.*, Kaya-Copur A., Nascimento Alves C., Matzat T., Spletter M.L., Luschnig S., Brasselet S., Lenne P., Schnorrer F. 2018. Polarization-resolved microscopy reveals a muscle myosin motor-independent mechanism of molecular actin ordering during sarcomere maturation. PLoS Biology. 16(4):e2004718.

DOI: 10.1371/journal.pbio.2004718


2015

Spletter M.L., Barz C., Yeroslaviz A., Schönbauer C., Ferreira I.R., Sarov M., Gerlach D., Stark A., Habermann B.H., Schnorrer F. 2015. The RNA-binding protein Arrest (Bruno) regulates alternative splicing to enable myofibril maturation in Drosophila flight muscle. EMBO Rep. 16 (2): 178-91.

DOI: 10.15252/embr.201439791


2014

Cao J., Ni J., Ma W., Shiu V., Milla L.A., Park S., Spletter M.L., Tang S., Zhang J., Wei X., Kim S.K., Scott M.P. 2014. Insight into insulin secretion from transcriptome and genetic analysis of insulin-producing cells of Drosophila. Genetics 197 (1): 175-92.

DOI: 10.1534/genetics.113.160663


Spletter M.L., Schnorrer F. 2014. Transcriptional regulation and alternative splicing cooperate in muscle fiber-type specification in flies and mammals. Exp Cell Res 321 (1): 90-8.

DOI: 10.1016/j.yexcr.2013.10.007


2012

Chen S., Spletter M.L., Ni X., White K.P., Luo L., Long M. 2012. Frequent recent origination of brain genes shaped the evolution of foraging behavior in Drosophila. Cell Rep 1 (2): 118-32.

DOI: 10.1016/j.celrep.2011.12.010


2010

Chou* Y.H., Spletter* M.L., Yaksi* E., Leong J.C.S., Wilson R.I., Luo L. 2010. Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe. Nature Neuroscience 13 (4): 439-49.

DOI: 10.1038/nn.2489


Li L., Tasic B., Micheva K.D., Ivanov V.M., Spletter M.L., Smith S.J., Luo L. 2010. Visualizing the distribution of synapses from individual neurons in the mouse brain. PLoS ONE 5 (7): e11503.

 DOI: 10.1371/journal.pone.0011503


pre-2010

Spletter M.L., Luo L. 2009. A new family of odorant receptors in Drosophila. Cell 136 (1): 23-5. 

DOI: 10.1016/j.cell.2008.12.031


Spletter M.L., Liu J., Liu J., Su H., Giniger E., Komiyama T., Quake S., Luo L. 2007. Lola regulates Drosophila olfactory projection neuron identity and targeting specificity. Neural Development 2: 14. 

DOI: 10.1186/1749-8104-2-14


Li J., Spletter M.L., Johnson J.A. 2005. Dissecting tBHQ induced ARE-driven gene expression through long and short oligonucleotide arrays. Physiol Genomics 21: 43-58.

DOI: 10.1152/physiolgenomics.00214.2004


Li J., Spletter M.L., Johnson D.A., Wright L.S., Svendsen C.N., Johnson J.A. 2005. Rotenone-induced caspase 9/3-independent and –dependent cell death in undifferentiated and differentiated human neural stem cells. J Neurochem 92: 462-76.

DOI: 10.1111/j.1471-4159.2004.02872.x


Spletter M.L. 2005. Photosynthesis in A. thaliana cotyledons with random, ordered and clustered stomata. In Yingst R.A., Brandt S.D., Rudd M., Borg J., Roethel A. (Eds.) 12th Annual Conference Space Ventures and 13th Annual Conference Our Changing Earth (pp. 45-53). University of Wisconsin-Green Bay: Wisconsin Space Grant Consortium.

Public Datasets

mRNA-Seq data #1

IFM browser tracks

mRNA-Seq data #1

IFM, TDT, leg, Bru1/Aret-IR IFM

from Spletter et al., EMBO Rep, 2015

GEO (GSE63707)

mRNA-Seq data #2

IFM browser tracks

mRNA-Seq data #1

8 timepoints of IFM development, salmIR and salm mutant IFM

from Spletter er al., Elife, 2018

GEO (GSE107247)

IFM browser tracks

IFM browser tracks

IFM browser tracks

IFM developmental timecourse read count data visualized as UCSC genome browser tracks

from Spletter er al., Elife, 2018

Hub1 - TC seq data

IFM browser tracks

IFM browser tracks

IFM browser tracks

Transcriptome changes in Bru1/Aret-IR and Salm-IR IFM;  UCSC genome browser tracks of read count data

from Spletter er al., Elife, 2018

HUB2 - Bru1,Salm IFM

mRNA-Seq data #3

IFM browser tracks

IFM browser tracks

Developmental leg datasets, updated mapping of IFM and mutant datasets

from Kao et al., J Vis Exp, 2019

GEO (GSE143430)

mRNA-Seq data #4

IFM browser tracks

mRNA-Seq data #4

control, SF1-IR and Hrb87F-IR IFM at 72 h APF

from Kao et al., Cells, 2021

GEO (GSE184001)

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